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Spastic Paraplegia: Disease Bioinformatics

Research of Spastic Paraplegia has been linked to Paraplegia, Spastic Paraplegia, Hereditary, Muscle Spasticity, Neurodegenerative Disorders, Atrophy. The study of Spastic Paraplegia has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Spastic Paraplegia include Pathogenesis, Transport, Cell Adhesion, Localization, Translation. These pathways complement our catalog of research reagents for the study of Spastic Paraplegia including antibodies and ELISA kits against APP, HSPD1, KIF5A, L1CAM, PLP1.

Top Research Reagents

We have 2732 products for the study of Spastic Paraplegia that can be applied to Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

L1CAM Antibody (UJ127.11) - BSA Free
NB100-2682
Western Blot: L1CAM Antibody (UJ127.11) [NB100-2682] - SUM159 cells were exposed to 20% or 1% O2 for 48 hours, whole cell lysates were loaded with 50 ug/lane. 10% SDS-PAGE. L1CAM Antibody (NB100-2682) primary antibody: 1:1000, 4C, overnight. Western blot image submitted by a verified customer review.Immunocytochemistry/Immunofluorescence: L1CAM Antibody (UJ127.11) [NB100-2682] - The left panel (A) shows untreated Neuro2a cells and the right panel (B) shows Neuro2a cells that were serum starved then treated with 1mM cAMP overnight to induce axon growth. Cells were fixed in 4% paraformaldehyde for 10 minutes and then permeabilized for 5 minutes using 1X PBS + 0.05% Triton-X100. The cells were incubated with anti- NB100-2682 at 5 ug/ml overnight at 4C and detected with an anti-mouse Dylight 488 (Green) at a 1:1000 dilution for 60 minutes. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 100X objective and digitally deconvolved.

Mouse Monoclonal
Species Human, Mouse
Applications WB, ELISA, Flow

     2 Reviews

4 Publications
REEP1 Antibody
NBP3-14647
Western Blot: REEP1 Antibody [NBP3-14647] - Anti-REEP1 rabbit polyclonal antibody at 1:500 dilutionLane A: Rat brain tissue lysate, lysates/proteins at 30 ug per lane.Secondary: Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.Developed using the ECL technique. Performed under reducing conditions.Predicted band size:22 kDaObserved band size:22 kDaImmunohistochemistry-Paraffin: REEP1 Antibody [NBP3-14647] - Immunochemical staining of human REEP1 in human testis with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.

Rabbit Polyclonal
Species Human
Applications WB, IHC-P, IP

SPG20 Antibody
NBP1-47203
Western Blot: SPG20 Antibody [NBP1-47203] - (2ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunocytochemistry/Immunofluorescence: SPG20 Antibody [NBP1-47203] - (2ug/ml) staining of methanol-fixed HeLa before (left) and after (right) introduction of siRNA.

Goat Polyclonal
Species Human
Applications WB, ICC/IF, PEP-ELISA

1 Publication
Kinesin 5A Antibody - BSA Free
NBP1-76816
Western Blot: Kinesin 5A Antibody [NBP1-76816] - K562 cell lysate with Kinesin 5A antibody at (A) 0.5 and (B) 1 ug/ml.Western Blot: Kinesin 5A Antibody [NBP1-76816] - Human samples tested and cleaned up bands after speaking with technical service and changing wash protocol. Image submitted by a verified customer review.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

     1 Review

SPG11 Antibody - BSA Free
NBP1-76990
Western Blot: SPG11 Antibody [NBP1-76990] - Mouse heart tissue lysate with SPG11 antibody at (A) 0.5 and (B) 1 ug/mL.Immunohistochemistry: SPG11 Antibody - BSA Free [NBP1-76990] - Immunohistochemistry of SPG11 in mouse brain tissue with SPG11 antibody at 2.5 ug/mL.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ELISA, IHC

HSP60 Antibody - BSA Free
NBP1-77397
Immunocytochemistry/Immunofluorescence: HSP60 Antibody [NBP1-77397] - HeLa cells were fixed in 4% paraformaldehyde for 10 minutes and permeabilized in 0.05% Triton X-100 in PBS for 5 minutes. The cells were incubated with HSP60 Antibody (NBP1-77397) at 1 ug/ml overnight at 4C and detected with an anti-rabbit Dylight 488 (Green) at a 1:1000 dilution for 60 minutes. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 100X objective and digitally deconvolved.Western Blot: HSP60 Antibody [NBP1-77397] - Analysis of extracts from HeLa and COS cells using NBP1-77397 Hsp60 antibody at 1:1000

Rabbit Polyclonal
Species Human, Mouse
Applications WB, Simple Western, Flow

     4 Reviews

6 Publications
Myelin PLP Antibody
NB100-74503
Western Blot: Myelin PLP Antibody [NB100-74503] - Proteins were extracted from control (Ctrl) and stretched (Stretch) 158N cells and western blot was performed for myelin protein PLP (26 kDa) following 20% of strain. Beta-Actin was used as a loading control. Results represent the mean +/- SEM of three independent experiments. Image collected and cropped by CiteAb from the following publication (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505516/) licensed under a CC-BY license.Western Blot: Myelin PLP Antibody [NB100-74503] - Figure 1 shows a Western blot of PLP in adult mouse brain samples using NB100-74503. Figure 2 shows an immunocytochemical staining of PLP in mouse brain thick section using NB100-74503. Staining (m) is limited to myelin tracts and oligodendrocytes.

Rabbit Polyclonal
Species Mouse, Rat
Applications WB, ICC/IF

7 Publications
RNF6 Antibody
NBP1-80251
Western Blot: RNF6 Antibody [NBP1-80251] - Titration: 1.25ug/ml Positive Control: SP2/0 cell lysate.Immunohistochemistry-Paraffin: RNF6 Antibody [NBP1-80251] - Mouse intestine, 4-8ug/ml.

Rabbit Polyclonal
Species Mouse
Applications WB, IHC, IHC-P

SPG7 Antibody (OTI1C1)
NBP2-01860
Western Blot: SPG7 Antibody (OTI1C1) [NBP2-01860] - Analysis of extracts (35 ug) from 9 different cell lines by using anti-SPG7 monoclonal antibody.Immunocytochemistry/Immunofluorescence: SPG7 Antibody (OTI1C1) [NBP2-01860] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY SPG7.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

     1 Review

3 Publications
beta Amyloid Antibody (MOAB-2) - BSA Free
NBP2-13075
IHC analysis of beta Amyloid on normal mouse brain (left) and 5xFAD mouse brain (right) using DAB with hematoxylin counterstain. The MOAB-2 antibody was used at 1:20 on normal mouse brain and at 1:400 on 5xFAD mouse brain.Analysis of beta Amyloid (MOAB-2) antibody in (1) 100 pmole beta Amyloid 42, (2) 5xFAD mouse brain homogenate Repetition 1 and (3) 5xFAD mouse brain homogenate Repetition 2.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, DB, ELISA

     2 Reviews

74 Publications
Als2 Antibody
NBP2-14284
Immunocytochemistry/Immunofluorescence: Als2 Antibody [NBP2-14284] - Over-expression of Alsin or Rab5 blocks caspase-3/7 activation.(A) HeLa cells transiently expressing empty vector, Alsin, or Rab5 were incubated in the presence of 500 uM H2O2 and 5 uM CellEvent caspase-3/7 green detection reagent at 37 degrees C for 2 hr. Nucleus was stained with DAPI (blue). Images were acquired by confocal microscopy. Caspase-activated cells displayed green signals, while non-activated cells (PBS control) showed no signal. Percent of cells with positive signals were quantified in (B), n = 50. Image collected and cropped by CiteAb from the following publication (elifesciences.org/articles/32282), licensed under a CC-BY license.Immunohistochemistry-Paraffin: Als2 Antibody [NBP2-14284] - Staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

1 Publication
Peroxiredoxin 5 Antibody [Unconjugated]
AF5724
Western blot shows lysates of human, mouse, and rat brain tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat Peroxiredoxin 5 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5724) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=Peroxiredoxin 5 was detected in immersion fixed A549 human lung carcinoma cell line using Goat Anti-Human/Mouse/Rat Peroxiredoxin 5 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5724) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # <a class=

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC

PTHLH/PTHrP Antibody (677939) [Unconjugated]
MAB6734
PTHLH/PTHrP was detected in immersion fixed paraffin-embedded sections of human colon using Mouse Anti-Human PTHLH/PTHrP Monoclonal Antibody (Catalog # MAB6734) at 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # <a class=

Mouse Monoclonal
Species Human
Applications IHC

2 Publications
VCAM-1/CD106 [HRP]
DVC00
N/A VCAM-1/CD106 [HRP]N/A VCAM-1/CD106 [HRP]


Species Human
Applications ELISA

121 Publications
SPG21 Antibody
NBP2-56164
Western Blot: SPG21 Antibody [NBP2-56164] - Western blot analysis in human cell line RT-4, human cell line U-251 MG, human plasma, human liver tissue and human tonsil tissue.Immunocytochemistry/Immunofluorescence: SPG21 Antibody [NBP2-56164] - Staining of human cell line A549 shows localization to cytosol & vesicles.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF

SPG3A Antibody (1B9)
H00051062-M03
Western Blot: SPG3A Antibody (1B9) [H00051062-M03] - Analysis of SPG3A expression in PC-12 (Cat # L012V1).Western Blot: SPG3A Antibody (1B9) [H00051062-M03] - Analysis of SPG3A expression in IMR-32 (Cat # L008V1).

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, IHC

1 Publication
Spastin Antibody (2F5)
H00006683-M02
Western Blot: Spastin Antibody (2F5) [H00006683-M02] - SPAST monoclonal antibody (M02), clone 2F5. Analysis of SPAST expression in Jurkat.Immunocytochemistry/Immunofluorescence: Spastin Antibody (2F5) [H00006683-M02] - Analysis of monoclonal antibody to SPAST on HeLa cell . Antibody concentration 10 ug/ml.

Mouse Monoclonal
Species Human
Applications WB, ELISA, ICC/IF

1 Publication
AAAS Antibody (5A1)
H00008086-M02
Western Blot: AAAS Antibody (5A1) [H00008086-M02] - AAAS monoclonal antibody (M02), clone 5A1. Analysis of AAAS expression in NIH/3T3.Immunohistochemistry-Paraffin: AAAS Antibody (5A1) [H00008086-M02] - Analysis of monoclonal antibody to AAAS on formalin-fixed paraffin-embedded human prostate. Antibody concentration 3 ug/ml.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, IHC

PDXP Antibody - Azide and BSA Free
NBP2-93574
Western Blot: PDXP Antibody [NBP2-93574] - Analysis of extracts of various cell lines, using PDXP at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit . Exposure time: 10s.Immunocytochemistry/Immunofluorescence: PDXP Antibody [NBP2-93574] - Immunofluorescence analysis of L929 cells using PDXP Rabbit pAb (NBP2-93574) at dilution of 1:100. Blue: DAPI for nuclear staining.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC