Home » Diseases » Papillon-lefevre Disease: Disease Bioinformatics
Novus Biologicals products are now on bio-techne.com
Submit your image related to Diseases to be featured!
Submit an Image

Get Social

Submit your Twitter account related to Papillon-lefevre Disease to be featured!
Submit an Account

Blogs

 Submit your blog on Papillon-lefevre Disease to be featured!
Submit a Blog

Events

 Submit your event on Papillon-lefevre Disease to be featured!
Submit an Event

Videos

Submit your video on Papillon-lefevre Disease to be featured!
Submit a Video

Charities

Submit your charity on Papillon-lefevre Disease to be featured!
Submit a Charity

Papillon-lefevre Disease: Disease Bioinformatics

Research of Papillon-lefevre Disease has been linked to Palmoplantar Keratosis, Periodontal Diseases, Periodontitis, Hyperkeratosis, Periodontitis, Juvenile. The study of Papillon-lefevre Disease has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Papillon-lefevre Disease include Pathogenesis, Chemotaxis, Keratinization, Phagocytosis, Immune Response. These pathways complement our catalog of research reagents for the study of Papillon-lefevre Disease including antibodies and ELISA kits against CD3, IL-1BETA, CALR, CD2, CTSC.

Top Research Reagents

We have 4185 products for the study of Papillon-lefevre Disease that can be applied to Chromatin Immunoprecipitation (ChIP), Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

NOD2 Antibody (2D9) - BSA Free
NB100-524
Western Blot: NOD2 Antibody (2D9) [NB100-524] - HCMV infection induces NOD2 mRNA and protein in HFFs and U373 cells. E. U373 glioma cells were infected with HCMV Towne strain and levels of NOD1, NOD2 and GAPDH mRNAs were measured by qRT-PCR at indicated time points. F. HFFs were infected with HCMV (Towne) at MOI of 1 PFU/cell and levels of NOD2 protein and B-actin were determined 48 and 72 hpi. G. HFFs were infected with HCMV (Towne) strain at MOI of 0.03 or 3 PFU/cell and levels of NOD2 protein and B-actin were determined at 48 hpi. Quantitative data represent mean values (+/-SD) of triplicate determinations from three independent experiments (*p<0.05, **p<0.01, ***p<0.001, one-way ANOVA test). Image collected and cropped by CiteAb from the following publication (//doi.org/10.1371/journal.pone.0092704.g001) licensed under a CC-BY license.Immunohistochemistry-Frozen: NOD2 Antibody (2D9) [NB100-524] - Overlay of NOD2-DyLight 488 (green) with phase contrast of murine colon. Image from verified customer review.

Mouse Monoclonal
Species Human, Mouse
Applications WB, Flow, ICC/IF

     1 Review

26 Publications
Calreticulin Antibody - BSA Free
NB600-101
Knockdown Validated: Calreticulin Antibody [NB600-101] - Western blot shows lysates of HeLa human cervical epithelial carcinoma parental cell line and Calreticulin knockout (KO) HeLa cell line. PVDF membrane was probed with 1:1500 of Rabbit Anti-Human Calreticulin Polyclonal Antibody (Catalog # NB600-101) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog #HAF008). Specific band was detected for Calreticulin at approximately 55 kDa (as indicated) in the parental HeLa cell line, but is not detectable in the knockout HeLa cell line. This experiment was conducted under reducing conditions.Western Blot: Calreticulin Antibody [NB600-101] - Human kidney lysate.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, DB

28 Publications
GCFC2 Antibody
H00006936-B01P
Western Blot: GCFC2 Antibody [H00006936-B01P] - Analysis of C2orf3 expression in transfected 293T cell line by C2orf3 polyclonal antibody. Lane 1: C2orf3 transfected lysate(23.76 KDa). Lane 2: Non-transfected lysate.Immunocytochemistry/Immunofluorescence: GCFC2 Antibody [H00006936-B01P] - Analysis of purified antibody to C2orf3 on HeLa cell. (antibody concentration 10 ug/ml)

Mouse Polyclonal
Species Human
Applications WB, ICC/IF

CD2 Antibody (RPA-2.10)
NBP2-25200
Flow Cytometry: CD2 Antibody (RPA-2.10) [NBP2-25200] - CD3+ T-Cells isolated from PBMCs stained with anti-CD2 Alexa Fluor 488 (BL1). Image from a verified customer review.Flow Cytometry: CD2 Antibody (RPA-2.10) [NBP2-25200] - Cell surface analysis of CD2 in 10^6 human lymphocytes using 0.25 ug of CD2 RPA-2.10 antibody; Shaded histogram represents cells without antibody; green represents isotype control ; red represents CD2 antibody. Goat anti-mouse IgG PE conjugated secondary was used in this test.

Mouse Monoclonal
Species Human
Applications WB, Flow, IHC

     1 Review

Cathepsin G Antibody
NBP2-33498
Immunohistochemistry-Paraffin: Cathepsin G Antibody [NBP2-33498] - Analysis in human bone marrow and cerebral cortex tissues. Corresponding Cathepsin G RNA-seq data are presented for the same tissues.Immunohistochemistry-Paraffin: Cathepsin G Antibody [NBP2-33498] - Staining of human testis shows no positivity in cells in seminiferous ducts as expected.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

5 Publications
Cathepsin C/DPPI Antibody [Unconjugated]
AF1034
Western blot shows lysates of mouse liver tissue and mouse spleen tissue. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Mouse Cathepsin C/DPPI Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1034) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=Western blot shows lysates of mouse lung tissue and rat lung tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Mouse Cathepsin C/DPPI Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1034) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=

Goat Polyclonal
Species Mouse, Rat
Applications WB, Simple Western, IHC

13 Publications
Plasma Kallikrein/KLKB1 Antibody [Unconjugated]
AF2498

Goat Polyclonal
Species Mouse
Applications WB, IP

4 Publications
Integrin beta 2/CD18 Antibody [Unconjugated]
AF1730
Integrin beta 2/CD18 was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs) using 10 µg/mL Goat Anti-Human Integrin beta 2/CD18 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1730) for 3 hours at room temperature. Cells were stained with the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; <a class=Integrin  beta 2/CD18 was detected in immersion fixed THP‑1 human acute monocytic leukemia cells (Positive) & absent in RT‑4 human urinary bladder transitional cell papilloma (Negative) using Goat Anti-Human Integrin  beta 2/CD18 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1730) at 5 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # <a class=NoLineLink href=

Goat Polyclonal
Species Human
Applications Flow, AdBlk, CyTOF-ready

16 Publications
Integrin beta 1/CD29 Antibody (P5D2) [Unconjugated]
MAB17781
Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human Integrin  beta 1/CD29 Monoclonal Antibody (Catalog # MAB17781, filled histogram) or isotype control antibody (Catalog # <A class=NoLineLink href=A549 human lung carcinoma cell line was stained with Mouse Anti-Human Integrin beta 1/CD29 Monoclonal Antibody (Catalog # MAB17781, filled histogram) or isotype control antibody (Catalog # <a class=

Mouse Monoclonal
Species Human
Applications Flow, IP, Block

35 Publications
TNF-alpha [Unconjugated]
210-TA
Recombinant Human TNF-alpha (Catalog # 210-TA) has a molecular weight (MW) of 53.1 kDa as analyzed by SEC-MALS, suggesting that this protein is a homotrimer.  MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation).Recombinant Human TNF-alpha (Catalog # 210‑TA) induces cytotoxicity in the L-929 mouse fibroblast cell line in the presence of the metabolic inhibitor actinomycin D. The ED<sub>50</sub> for this effect is 25‑100 pg/mL.


Species Human
Applications BA

     3 Reviews

817 Publications
IL-2 [Unconjugated]
202-IL
As an alternative, please consider our next generation Recombinant Human IL-2 (<a class=


Species Human
Applications BA

     4 Reviews

377 Publications
CXCL8/IL-8 [Biotin]
DY208
N/A CXCL8/IL-8 [Biotin]


Species Human
Applications ELISA

464 Publications
Neutrophil Elastase/ELA2 [Biotin]
DY9167-05
N/A Neutrophil Elastase/ELA2 [Biotin]


Species Human
Applications ELISA

21 Publications
Tyrosinase Antibody (JA52-11)
NBP2-67232
Western Blot: Tyrosinase Antibody (JA52-11) [NBP2-67232] - Western blot analysis of Tyrosinase on B16F1 cell lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (1/500) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:200,000 dilution was used for 1 hour at room temperature.Immunocytochemistry/Immunofluorescence: Tyrosinase Antibody (JA52-11) [NBP2-67232] - Staining Tyrosinase in B16F1 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Rabbit Monoclonal
Species Human, Mouse
Applications WB, ICC/IF, IHC

Granzyme B [Biotin]
DY1865
N/A Granzyme B [Biotin]


Species Mouse
Applications ELISA

32 Publications
Proteinase 3/Myeloblastin/PRTN3 Antibody
NBP1-25966
Western Blot: Proteinase 3/Myeloblastin/PRTN3 Antibody [NBP1-25966] - Human PMN (peripheral blood mononuclear cells isolated from buffycoat; denatured, reduced) using Rabbit antibody to c-terminal region of Pr3 (Wegener autoantigen): whole serum at 1: 500 dilution; blocked with 1% LFDM for 15 minutes at room temperature with shake, primary antibody incubated for 15 minutes at room temperature, washed 3 times with PBST, 5 minutes each. Secondary antibody was also incubated for 15 minutes at room temperature.Immunocytochemistry/Immunofluorescence: Proteinase 3/Myeloblastin/PRTN3 Antibody [NBP1-25966] - Human PBMC were isolated and adjusted to 106 cells. Cells were fixed with 2% formaldehyde for 10 min at 37C. Washed twice with PBS before cytospin the cells onto microscope slides. Cells were blocked with PBS containing 1%BSA for 20 min at RT. Excess of blocking solution was removed and cells were then incubated with Rabbit Ab to c-terminal region of Pr3 (Wegener autoantigen): whole serum for 30 min at RT (diluted 1:100 in the blocking buffer). Washed 3X with PBS and incubated with anti-Rabbit Alexa 586 for further 30 min. Washed as before and nuclear counterstained with DAPI. Neutrophils and Monocytes, known to have PR3 are intensely stained by the Rabbit Ab to c-terminal region of Pr3 (Wegener autoantigen): whole serum.

Rabbit Polyclonal
Species Human
Applications WB, Flow, ICC/IF

2 Publications
DSPP Antibody - Azide and BSA Free
NBP2-92546
Western Blot: DSPP Antibody [NBP2-92546] - Analysis of lysates from wild type (WT) and 293F cells transfected with DSPP using DSPP Rabbit pAb at 1:1000 dilution. Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)at 1:10000 dilution.Lysates/proteins: 40.5 ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit. Exposuretime: 10s.ICC/IF:DSPP Antibody [NBP2-92546] - Analysis of Dental pulp stem cell using DSPP Rabbit pAb at a dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (AS007) at 1:500 dilution. Blue: DAPI for nuclear staining.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ELISA, ICC/IF

3 Publications
Pescadillo Antibody
NB110-40548
Western Blot: Pescadillo Antibody [NB110-40548] - Detection of human Pescadillo by western blot. Samples: Whole cell lysate (50 ug) from HeLa, HEK293T, and Jurkat cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-Pescadillo antibody NB110-40548 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.Immunohistochemistry: Pescadillo Antibody [NB110-40548] - Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti- Pescadillo used at a dilution of 1:200 (1ug/ml). Detection: DAB

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

1 Publication

Related Genes

Papillon-lefevre Disease has been researched against:

Related Pathways

Papillon-lefevre Disease has been linked to:

Related Diseases

Papillon-lefevre Disease has been studied in relation to diseases such as:

Related PTMs

Papillon-lefevre Disease has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Papillon-lefevre Disease is also known as papillon-lefevre disease, papillon-lefevre syndrome, keratosis palmoplantaris with periodontopathia, papillon lefevre syndrome, palmar-plantar hyperkeratosis and concomitant periodontal destruction, hyperkeratosis palmoplantaris with periodontosis, keratoris palmoplantaris with periodontopathia, palmoplantar keratoderma with periodontosis, papillon-lefvre syndrome (disorder), actinic keratosis, pals.