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Narcolepsy: Disease Bioinformatics

Narcolepsy is a neurological disorder affecting the part of the brain that regulates sleep. Those suffering from narcolepsy can experience excessive daytime sleepiness, hallucinations, and sudden loss of muscle control. A normal sleep cycle is about 100 to 110 minutes, beginning with NREM (non rapid eye movement) sleep and transitioning to REM(rapid eye movement) sleep after 80 to 100 minutes. People with narcolepsy frequently enter REM sleep within a few minutes of falling asleep. Narcolepsy effects both men and women equally and is widespread throughout the world. It mostly begins during a person’s childhood and is lifelong. Diagnosis of the condition can take a long time in most cases more than a year and sometimes as long as several decades because narcolepsy symptoms are often mistakenly linked to other sleep disorders or medical conditions such as depression. The only unique symptom of narcolepsy is cataplexy this happens when you lose the ability to control your muscles. Narcolepsy with cataplexy is estimated to affect about one in every 2,000 people in the USA. When cataplexy is present, narcolepsy is almost always caused by the lack of a brain neurotransmitters called hypocretin. Neurotransmitters are chemicals that neurons produce to communicate with each other. Loss of hypocretin results in an inability to regulate sleep. In cases without cataplexy, the disorder may be caused by a lack of hypocretin or by various other causes. People with narcolepsy can fight off the urge to fall asleep with exercise this will keep your heart rate elevated and more awake during the day.

Top Research Reagents

We have 2952 products for the study of Narcolepsy that can be applied to Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

PNPLA6 Antibody (3D10)
H00010908-M08
Western Blot: PNPLA6 Antibody (3D10) [H00010908-M08] - Analysis of PNPLA6 expression in transfected 293T cell line by NTE monoclonal antibody (M08), clone 3D10. Lane 1: PNPLA6 transfected lysate (Predicted MW: 146.2 KDa). Lane 2: Non-transfected lysate.Immunohistochemistry-Paraffin: PNPLA6 Antibody (3D10) [H00010908-M08] - Analysis of monoclonal antibody to PNPLA6 on formalin-fixed paraffin-embedded human small Intestine. Antibody concentration 3 ug/ml

Mouse Monoclonal
Species Human
Applications WB, ELISA, IHC

Ataxin-3 Antibody (HL1909) - Azide and BSA Free
NBP3-25371
Immunohistochemistry-Paraffin: Ataxin-3 Antibody (HL1909) - Azide and BSA Free [NBP3-25371] - Ataxin 3 antibody [HL1909] detects Ataxin 3 protein at nucleus by immunohistochemical analysis. Sample: Paraffin-embedded rat brain. Ataxin 3 stained by Ataxin 3 antibody [HL1909] (NBP3-25371) diluted at 1:100. Antigen Retrieval: Citrate buffer, pH 6.0, 15 minKnockdown Validated: Ataxin-3 Antibody (HL1909) - Azide and BSA Free [NBP3-25371] - Non-transfected (-) and transfected (+) 293T whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with Ataxin 3 antibody [HL1909] (NBP3-25371) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.

Rabbit Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

Orexin R2/HCRTR2 Antibody (1E3)
H00003062-M01
Western Blot: Orexin R2/HCRTR2 Antibody (1E3) [H00003062-M01] - Analysis of HCRTR2 expression in transfected 293T cell line by HCRTR2 monoclonal antibody (M01), clone 1E3.Lane 1: HCRTR2 transfected lysate(50.7 KDa).Lane 2: Non-transfected lysate.Western Blot: Orexin R2/HCRTR2 Antibody (1E3) [H00003062-M01] - Analysis of HCRTR2 over-expressed 293 cell line, cotransfected with HCRTR2 Validated Chimera RNAi ( Cat # H00003062-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with HCRTR2 monoclonal antibody (M01), clone 1E3 (Cat # H00003062-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.

Mouse Monoclonal
Species Human
Applications WB, ELISA, KD

     1 Review

1 Publication
LIFR alpha Antibody [Unconjugated]
AF-249-NA
Recombinant Human LIF stimulates proliferation in the TF‑1 human erythroleukemic cell line in a dose-dependent manner (orange line). Proliferation elicited by 0.3 ng/mL Recombinant Human LIF is neutralized (green line) by increasing concentrations of Goat Anti-Human LIF R alpha Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-249-NA). The ND<SUB>50</SUB> is typically 6-36 µg/mL.

Goat Polyclonal
Species Human
Applications WB, Neut

16 Publications
CD200R1 Antibody [Unconjugated]
AF2554
CD200 R1 was detected in immersion fixed mouse splenocytes using Goat Anti-Mouse CD200 R1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2554) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # <a class=

Goat Polyclonal
Species Mouse
Applications WB, Flow, CyTOF-ready

8 Publications
CTNNBL1 Antibody (1E4F5) - BSA Free
NBP2-37252
Western Blot: CTNNBL1 Antibody (1E4F5) [NBP2-37252] - Western blot analysis using CTNNBL1 mouse mAb against Hela (1), Jurkat (2), HEK293 (3), A431 (4), HepG2 (5), RAJI (6) cell lysate.Immunocytochemistry/Immunofluorescence: CTNNBL1 Antibody (1E4F5) [NBP2-37252] - Immunofluorescence analysis of MCF-7 cells using CTNNBL1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Goat anti-Mouse IgG (H+L) DyLight 488 secondary antibody was used.

Mouse Monoclonal
Species Human
Applications WB, ELISA, Flow

TNF-alpha [Unconjugated]
210-TA
Recombinant Human TNF-alpha (Catalog # 210-TA) has a molecular weight (MW) of 53.1 kDa as analyzed by SEC-MALS, suggesting that this protein is a homotrimer.  MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation).Recombinant Human TNF-alpha (Catalog # 210‑TA) induces cytotoxicity in the L-929 mouse fibroblast cell line in the presence of the metabolic inhibitor actinomycin D. The ED<sub>50</sub> for this effect is 25‑100 pg/mL.


Species Human
Applications BA

     3 Reviews

811 Publications
GM-CSF [Unconjugated]
7954-GM/CF
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED<sub>50</sub> for this effect is 6-30 pg/mL.


Species Human
Applications BA

3 Publications
Orexin A/Hypocretin-1 Antibody (97505) [Unconjugated]
MAB763
Orexin A/Hypocretin‑1 was detected in immersion fixed paraffin-embedded sections of Mouse Hypothalamus using Mouse Anti-Human/Mouse Orexin A/Hypocretin‑1 Monoclonal Antibody (Catalog # MAB763) at 5 µg/mL overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # <a class=NoLineLink href=

Mouse Monoclonal
Species Human, Mouse
Applications IHC

19 Publications
LAMC2 Antibody (CL2980)
NBP2-42388
Immunohistochemistry-Paraffin: LAMC2 Antibody (CL2980) [NBP2-42388] - Staining in human fallopian tube and liver tissues. Corresponding LAMC2 RNA-seq data are presented for the same tissues.Western Blot: LAMC2 Antibody (CL2980) [NBP2-42388] - Analysis in A-431 cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-LAMC2 antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.

Mouse Monoclonal
Species Human
Applications WB, ICC/IF, IHC

4 Publications
HLA DRB1 Antibody (SPM288)
NBP2-45312
Western Blot: HLA DRB1 Antibody (SPM288) [NBP2-45312] - Western Blot Analysis of Ramos cells and human spleen tissue lysate using HLA DRB1 Antibody (SPM288).Immunohistochemistry-Paraffin: HLA DRB1 Antibody (SPM288) [NBP2-45312] - Formalin-fixed, paraffin-embedded human Tonsil stained with HLA DRB1 Antibody (SPM288).

Mouse Monoclonal
Species Human, Monkey, Mouse (Negative)
Applications WB, Flow, ICC/IF

2 Publications
c-Fos Antibody (2H2)
NBP2-50037
Western Blot: c-Fos Antibody (2H2) [NBP2-50037] - Top panel: Analysis of c-Fos expression in HeLa cells using NBP2-50037. Lane 1: HeLa cells were serum-starved for 36 hours. Lane 2: Serum-starved HeLa cells were stimulated with 20% FBS (fetal bovine serum) for 2 hours. NBP2-50037 recognizes bands in the range of 50-65 kDa, which represent multiple forms of c-Fos. Serum starvation attenuates c-Fos expression, while 20% FBS strongly stimulates c-Fos expression. Bottom panel: Blot was stripped and probed with monoclonal antibody against GAPDH (NB300-221) used as loading control.Immunocytochemistry/Immunofluorescence: c-Fos Antibody (2H2) [NBP2-50037] - Section of rat hippocampus stained with mouse monoclonal antibody to c-FOS NBP2-50037 in red and counterstained with rabbit polyclonal antibody to FOX3/NeuN. DAPI reveals nuclei of neurons and glia in blue. The hippocampal neurons stain green for FOX3/NeuN and a few also are expressing c-FOS, and so appear orange. These cells were spontaneously active at the time the animal was sacrificed.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

     1 Review

20 Publications
Recombinant Human HLA DRB4 GST (N-Term) Protein
H00003126-P01
12.5% SDS-PAGE Stained with Coomassie Blue.


Species Human
Applications WB, ELISA, PA

1 Publication
REM1 Antibody
H00028954-B01P
Western Blot: REM1 Antibody [H00028954-B01P] - Analysis of REM1 expression in transfected 293T cell line by REM1 polyclonal antibody. Lane 1: REM1 transfected lysate(32.78 KDa). Lane 2: Non-transfected lysate.Immunocytochemistry/Immunofluorescence: REM1 Antibody [H00028954-B01P] - Analysis of purified antibody to REM1 on HeLa cell. (antibody concentration 10 ug/ml)

Mouse Polyclonal
Species Human
Applications WB, ICC/IF

CENPJ Antibody (1A5)
H00055835-M02
Western Blot: CENPJ Antibody (1A5) [H00055835-M02] - Analysis of CENPJ expression in transfected 293T cell line by CENPJ monoclonal antibody (M02), clone 1A5.Lane 1: CENPJ transfected lysate(43.2 KDa).Lane 2: Non-transfected lysate.Immunoprecipitation: CENPJ Antibody (1A5) [H00055835-M02] - Analysis of CENPJ transfected lysate using anti-CENPJ monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with CENPJ MaxPab rabbit polyclonal antibody.

Mouse Monoclonal
Species Human
Applications WB, ELISA, IP

Leptin/OB [HRP]
MOB00B
N/A Leptin/OB [HRP]N/A Leptin/OB [HRP]


Species Mouse, Rat
Applications ELISA

192 Publications