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Congenital Anomaly Of Brain: Disease Bioinformatics

There are a large number of congenital anomalies that involve the cranium and the brain and occur as a result of disorders that are present before or at birth. The anomalies stem from developmental issues of the nervous system, and they typically lead to debilitating disorders as well as death in some cases. There is not a single factor which causes brain and cranium anomalies, but can be the effect of genetic conditions, medicines taken during pregnancy, maternal infection, or radiation. An example of congenital brain and cranium anomalies includes anencephaly, where the cephalic end of the neural tube doesn’t close, which results in the baby being born without a forebrain and is blind, deaf and unconsciousness, and has a very small chance of ever waking up. Other common congenital brain and cranium anomalies are colpocephaly, holoprosencephaly, hydranencephaly, iniencephaly, lissencephaly, megalencephaly, microcephaly, porencephaly and schizencephaly.

Top Research Reagents

We have 985 products for the study of Congenital Anomaly Of Brain that can be applied to Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

NBP3-15472
Western Blot: FKTN Antibody (7J5N6) [NBP3-15472] - Western blot analysis of extracts of various cell lines, using FKTN antibody (NBP3-15472) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.Immunohistochemistry-Paraffin: FKTN Antibody (7J5N6) [NBP3-15472] - Immunohistochemistry of paraffin-embedded human colon using FKTN Rabbit mAb (NBP3-15472) at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.

Rabbit Monoclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P

H00002316-M01
Western Blot: Filamin A Antibody (4E10-1B2) [H00002316-M01] - FLNA monoclonal antibody (M01), clone 4E10-1B2 Analysis of FLNA expression in HL-60.Immunohistochemistry-Paraffin: Filamin A Antibody (4E10-1B2) [H00002316-M01] - Analysis of monoclonal antibody to FLNA on formalin-fixed paraffin-embedded human lymphoma tissue. Antibody concentration 1.5 ug/ml.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

14 Publications
NBP1-72042
Western Blot: Doublecortin Antibody [NBP1-72042] - staining of Mouse fetal Brain lysate (35 ug protein in RIPA buffer). Antibody at 0.01 ug/mL. Primary incubation was 1 hour. Detected by chemiluminescence.Immunocytochemistry/Immunofluorescence: Doublecortin Antibody [NBP1-72042] - Immunofluorescence analysis of paraformaldehyde fixed KNRK cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL), showing cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL).

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

5 Publications
H00006496-M04
Western Blot: Six3 Antibody (1A2) [H00006496-M04] - Analysis of SIX3 expression in FHs 173 WE.Western Blot: Six3 Antibody (1A2) [H00006496-M04] - Analysis of SIX3 expression in 293 (Cat # L026V1).

Mouse Monoclonal
Species Human
Applications WB, ELISA

NBP1-87769
Immunohistochemistry-Paraffin: LIS1 Antibody [NBP1-87769] - Analysis in human testis and liver tissues using NBP1-87769 antibody. Corresponding PAFAH1B1 RNA-seq data are presented for the same tissues.Western Blot: LIS1 Antibody [NBP1-87769] - Analysis of LIS1 in caco-2 whole cell lysate using anti-LIS1 antibody.  Image submitted by a verified customer review.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

     2 Reviews

NBP2-03688
Western Blot: SAE2 Antibody (4A3) [NBP2-03688] Analysis of extracts (35ug) from 9 different cell lines by using anti-SAE2 monoclonal antibody.Immunocytochemistry/Immunofluorescence: SAE2 Antibody (4A3) [NBP2-03688] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY SAE2.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

NBP2-24607
Western Blot: Zic2 Antibody [NBP2-24607] - Analysis of ZIC2 in HepG2 cell lysate using 1) pre-bleed, and 2) this antibody.  Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

Rabbit Polyclonal
Species Human, Mouse, Bovine
Applications WB

AF3820
Reelin was detected in immersion fixed frozen sections of mouse embryo (13 d.p.c.) using Goat Anti-Mouse Reelin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3820) at 1.7 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # <a class=

Goat Polyclonal
Species Mouse
Applications WB, IHC

23 Publications
AF4634
Western blot shows lysates of human brain (cortex) tissue and human brain (hippocampus) tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human GPR56 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4634) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # <a class=Human peripheral blood lymphocytes were stained with (A) Sheep Anti-Human GPR56 Affinity-purified Polyclonal Antibody (Catalog # AF4634) or (B) control antibody (Catalog # <a class=

Sheep Polyclonal
Species Human
Applications WB, Simple Western, Flow

4 Publications
AF7068
Western blot shows lysates of U-87 MG human glioblastoma/astrocytoma cell line, U-118-MG human glioblastoma/astrocytoma cell line, and human brain (cortex) tissue. PVDF membrane was probed with 2 µg/mL of Sheep Anti-Human ARX Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7068) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # <a class=ARX was detected in immersion fixed U-87 MG human glioblastoma/astrocytoma cell line using Sheep Anti-Human ARX Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7068) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red, upper panel; Catalog # <a class=

Sheep Polyclonal
Species Human
Applications WB, IHC, ICC

11 Publications
MAB7555
Western blot shows lysates of HCT-116 human colorectal carcinoma cell line, JAR human choriocarcinoma cell line, and A549 human lung carcinoma cell line. PVDF membrane was probed with 0.1 µg/mL of Mouse Anti-Human TGIF1 Monoclonal Antibody (Catalog # MAB7555) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # <a class=Simple Western lane view shows lysates of HCT‑116 human colorectal carcinoma cell line, loaded at 0.5 mg/mL. A specific band was detected for TGIF1 at approximately 38 kDa (as indicated) using 1 µg/mL of Mouse Anti-Human TGIF1 Monoclonal Antibody (Catalog # MAB7555). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Mouse Monoclonal
Species Human
Applications WB, Simple Western

1 Publication
AF6868
Western blot shows lysates of MCF-7 human breast cancer cell line, SH-SY5Y human neuroblastoma cell line, human muscle tissue, and human placenta tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human Dystroglycan Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6868) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # <a class=Dystroglycan was detected in immersion fixed paraffin-embedded sections of human skeletal muscle using Sheep Anti-Human Dystroglycan Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6868) at 3 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # <a class=

Sheep Polyclonal
Species Human
Applications WB, IHC, KO

23 Publications
7414-GT


Species Human
Applications EnzAct

1 Publication
DPLG70
N/A PLA2G7/PAF-AH/Lp-PLA2 [HRP]N/A PLA2G7/PAF-AH/Lp-PLA2 [HRP]


Species Human
Applications ELISA

     1 Review

14 Publications
464-SH
Recombinant Mouse Sonic Hedgehog/Shh (C25Il), N-Terminus (Catalog # 464-SH) induces alkaline phosphatase production by the C3H10T1/2 mouse embryonic fibroblast cell line. The activity is more than 30-fold greater than the top competitor's Sonic Hedgehog.Recombinant Mouse Sonic Hedgehog/Shh (C25II), N-Terminus (Catalog # 464-SH) has a molecular weight (MW) of 20.7 kDa as analyzed by SEC-MALS, suggesting that this protein is a monomer.  MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation).


Species Mouse
Applications BA

70 Publications
H00079147-Q01
12.5% SDS-PAGE Stained with Coomassie Blue.


Species Human
Applications WB, ELISA, PA

NB110-41404
Western Blot: Glutamine Synthetase Antibody [NB110-41404] - Analysis of glutamine synthase. 40ug of lysates from mouse (Lanes M), rat (Lane R), pig (Lane P), bovine (Lane B), or human (Lane Hu) retina were probed. A 42 kDa band was identified in lysates from retinas of all species.Immunocytochemistry/Immunofluorescence: Glutamine Synthetase Antibody [NB110-41404] - Immunofluorescence using NB110-41404. Submitted via verified customer review.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

     1 Review

11 Publications
NBP3-12334
Western Blot: POMT2 Antibody [NBP3-12334] - 1. Rat cortex, 2. Rat heart, 3. C2C12 cells. Apparent MW is 85-90 KDa. 1:250 Dilution DilObuffer.Immunohistochemistry-Paraffin: POMT2 Antibody [NBP3-12334] - Baboon Colon.1:100 dilution in IHC blocking buffer. DAB (brown) staining and Hematoxylin QS (blue) counterstain. 40X magnification.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ELISA, IHC

NBP3-12487
Immunohistochemistry-Paraffin: POMT1 Antibody [NBP3-12487] - 1:100 dilution in IHC blocking buffer. DAB (brown) staining and Hematoxylin QS (blue) counterstain. 40x magnification.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ELISA, IHC


Related Genes

Congenital Anomaly Of Brain has been researched against:

Related PTMs

Congenital Anomaly Of Brain has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Congenital Anomaly Of Brain is also known as Brain Malformation, Brain Malformations, Congenital Brain Anomaly, Deformity Of Brain.