Cyclophilin 40 Products

Description

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents: cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. CyP 40, a 40 kDa protein, shares significant homology with smaller CyPA (CyP 18) and FKBP59. CyP 40 exhibits the characteristic CsA binding and isomerase activity of CyP 18, though these activities appear to be less with CyP 40 than with Cyp 18. Like FKBP59, CyP 40 has been found in progesterone receptor complexes. CyP 40 is expressed at similar levels in many tissues.

Bioinformatics

Entrez	361967 Rat 5481 Human 67738 Mouse
Uniprot	NM_005038 Human NP_005029 Human NP_005029.1 Human Q08752 Human
Product By Gene ID	5481
Alternate Names	40 kDa peptidyl-prolyl cis-trans isomerase D 40 kDa peptidyl-prolyl cis-trans isomerase cyclophilin D cyclophilin-40 Cyclophilin-40 Cyclophilin-related protein CYP40 CYP-40cyclophilin 40 CYPD EC 5.2.1.8 MGC33096 peptidyl-prolyl cis-trans isomerase D peptidylprolyl isomerase D (cyclophilin D) peptidylprolyl isomerase D PPIase D Rotamase D

Research Areas for Cyclophilin 40

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Immunology