ZNF198 Products

Description

Official Gene Symbol: ZMYM2 Gen Bank Accession Number: NP_932072 Gene ID: 7750 (Human) Gene Map Locus: 13q11-q12 (Human) ZNF198 is a ubiquitously expressed nuclear protein whose physiological role is largely unknown. It consists of 5 N-terminal zinc finger motifs responsible for protein-protein interactions, a central proline-rich domain and C-terminal nuclear localization signal (NLS) and an acidic domain. Reciprocal chromosomal translocation involving ZNF198 and FGFR1 results in the formation of ZNF198/FGFR1 fusion kinase protein. This fusion protein is a ligand-dependent, constitutively active cytoplasmic tyrosine kinase and regulates several STAT transcription factors including STAT 1, 3 and 5. This fusion protein is an oncogenic protein and is associated with an atypical myeloproliferative disease, peripheral blood eosinophilia and T-cell leukemia/lymphoma.

Bioinformatics

Entrez	305913 Rat 76007 Mouse 7750 Human
Uniprot	CAH71822 Human NP_003444.1 Human NP_932072 Human Q9UBW7 Human
Product By Gene ID	7750
Alternate Names	FIMRAMPSCLL Fused in myeloproliferative disorders protein MYM Rearranged in atypical myeloproliferative disorder protein Zinc finger protein 198rearranged in an atypical myeloproliferative disorder zinc finger, MYM-type 2 ZNF198zinc finger MYM-type protein 2