Description
The transcriptional coactivator Yes-associated protein (YAP), also known as Yes-associated protein 1 (
YAP1), Yes-Associated Protein YAP65 Homolog, Protein Yorkie Homolog and YAP65 has a theoretical molecular weight of 65 kDa. The YAP1 gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the
Yes proto-oncogene product. YAP1 shares homology with the WW domain of transcriptional co-activator with PDZ-binding motif (
TAZ), which functions as a transcriptional co-activator by binding to the PPXY motif present in
transcription factors and is likely involved in protein-protein interaction. YAP has been identified as a core regulatory mechanism that blocks mammalian glial cell proliferation and cellular reprogramming following damage (1).
YAP plays a role in the development and progression of multiple
cancers as a transcriptional regulator of the
Hippo signaling pathway. YAP1 encodes a nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis to play a pivotal role in controlling cell growth and organ size and has emerged as a key player in
tumor suppression (2,3). Deregulation of the Hippo pathway causes tumor formation and malignancy, with YAP being a key oncogenic driver in liver carcinogenesis (2) and may function as a potential target for cancer treatment (3).
References
1. Rueda, E. M., Hall, B. M., Hill, M. C., Swinton, P. G., Tong, X., Martin, J. F., & Poche, R. A. (2019). The Hippo Pathway Blocks Mammalian Retinal Muller Glial Cell Reprogramming. Cell Rep, 27(6), 1637-1649.e1636. doi:10.1016/j.celrep.2019.04.047
2. Liu, A. M., Xu, M. Z., Chen, J., Poon, R. T., & Luk, J. M. (2010). Targeting YAP and Hippo signaling pathway in liver cancer. Expert Opin Ther Targets, 14(8), 855-868. doi:10.1517/14728222.2010.499361
3.Ye, S., & Eisinger-Mathason, T. S. (2016). Targeting the Hippo pathway: Clinical implications and therapeutics. Pharmacol Res, 103, 270-278. doi:10.1016/j.phrs.2015.11.025
Bioinformatics
| Entrez |
Human
Mouse
Rat
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
10413 |
| Alternate Names |
- 65 kDa Yes-associated protein
- COB1
- Protein Yorkie Homolog
- Transcriptional Coactivator YAP1
- YAP
- YAP1-2gamma
- YAP2
- YAP2L
- YAP65
- YAP65yes-associated protein 2
- Yes Associated Protein
- Yes-associated protein 1
- Yes-associated protein 1, 65kDa
- yes-associated protein beta
- yes-associated protein delta
- Yes-Associated Protein YAP65 Homolog
- Yes-Associated Protein
- YKI
- yorkie homolog
|
