UGT1A9 Products

Description

UGT1A9 encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. [provided by RefSeq]

Bioinformatics

Entrez	54600 Human
Uniprot	NM_021027 Human NP_066307 Human NP_066307.1 Human O60656 Human
Product By Gene ID	54600
Alternate Names	EC 2.4.1.17 GNT1 HLUGP4 LUGP4 lugP4 polypeptide A9 UDP glucuronosyltransferase 1 family, polypeptide A9 UDP-glucuronosyltransferase 1-9 UDP-glucuronosyltransferase 1A9 UDP-glucuronosyltransferase 1-I UDPGT 1-9 UDPGT UGT1 UGT1*9 UGT1.9 UGT1-09 UGT1-9 UGT1AI UGT1I UGT-1I

Research Areas for UGT1A9

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Cancer