UEV2 Products

Description

The differentiation and activation of monocytes (MO) and monocytic cells is modulated by Vitamin D3. Recently, using mRNA Differential Display technology, Fritsche J, et al have identified a gene which is induced in freshly isolated human blood MO that are cultured for 4 hours with Vitamin D3. This cDNA encodes a putative 16.5 kD protein. The product of this gene has structural homology with yeast MMS2P and human CROC-1, which defines a structurally and functionally conserved UBC-like protein family. This protein was called UEV2. The yeast UEV protein is required together with UBC13 for RAD6/RAD18-dependent postreplicative DNA repair in yeast. These proteins also play a central role in the assembly of K63-linked polyubiquitin chains UEV/UBC complexes have been implicated in the assembly of Lys63-linked polyubiquitin chains that act as a novel signal in postreplicative DNA repair and IkBa kinase activation. Recent crystal structure analysis provides direct evidence that the UEV2 heterodimer is necessary for DNA repair.

Bioinformatics

Entrez	70620 Mouse 7336 Human
Uniprot	AAH07051 Human NM_003350 Human NP_003341 Human NP_003341.1 Human Q15819 Human
Product By Gene ID	7336
Alternate Names	1 alpha 25-dihydroxyvitamin D3-inducible DDVIT1 DDVit-1 EDAF-1 EDPF1 EDPF-1DDVit 1 enterocyte differentiation promoting factor Enterocyte differentiation-associated factor 1 enterocyte differentiation-associated factor EDAF-1 Enterocyte differentiation-promoting factor 1 methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of MMS2MMS2 homolog ubiquitin-conjugating enzyme E2 variant 2 UEV2 UEV-2 Vitamin D3-inducible protein

Research Areas for UEV2

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Core ESC-Like Genes
Stem Cell Markers