TRPV6 Products

Description

Calcium-permeable channels, such as TRPV6, participate in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger. Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA); FUNCTION: Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. SUBUNIT: Homotetramer and probably heterotetramer with TRPV5. Interacts with TRPV5. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with BSPRY. Interacts with calmodulin. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.

Bioinformatics

Entrez	55503 Human
Uniprot	NM_018646 Human Q9H1D0 Human
Product By Gene ID	55503
Alternate Names	ABP/ZF calcium channel CaT1 Calcium transport protein 1 CAT1 CaT1 CATL CaT-L CaT-like ECaC2 ECAC2caT-L epithelial apical membrane calcium transporter/channel CaT1 Epithelial calcium channel 2Alu-binding protein with zinc finger domain HSA277909 LP6728 transient receptor potential cation channel subfamily V member 6 transient receptor potential cation channel, subfamily V, member 6 TrpV6 ZFAB

Research Areas for TRPV6

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Signal Transduction

Related TRPV6 Blog Posts

Check out the latest blog posts on TRPV6.

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