TORC1 Products

Description

MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1, Transducer of regulated cAMP response element-binding protein 1, TORC1, and Transducer of CREB protein 1) is a nuclear protein that functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein.

Bioinformatics

Entrez	23373 Human 382056 Mouse 684527 Rat
Uniprot	NP_001091952 Human NP_056136 Human Q6UUV9 Human
Product By Gene ID	23373
Alternate Names	CREB regulated transcription coactivator 1 FLJ14027WAMTP1 KIAA0616Transducer of regulated cAMP response element-binding protein 1 MECT1CREB-regulated transcription coactivator 1 mucoepidermoid carcinoma translocated 1 Mucoepidermoid carcinoma translocated protein 1 TORC1TORC-1 Transducer of CREB protein 1 transducer of regulated cAMP response element-binding protein (CREB) 1

Research Areas for TORC1

Find related products by research area and learn more about each of the different research areas below.

Protein Kinase