TIP60 Products

Description

HTATIP (HIV-1 Tat interacting protein TIP60, about 60kDa) belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. In addition to the growing number of post-translational histone modifications regulating chromatin structure, cells can also exchange canonical histones with variant histones that can directly or indirectly modulate chromatin structure. There are five major variants of histone H2A: canonical H2A (most abundant), H2A.X, MacroH2A, H2ABbd and H2A.Z. Histone H2A.Z, the most conserved variant across species, functions as both a positive and negative regulator of transcription and is important for chromosome stability. Several homologous protein complexes, such as SWR-C, TIP60 and SRCAP (mammals), have been shown to catalyze the ATP-dependent exchange of H2A.Z for H2A in the nucleosome. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.

Bioinformatics

Entrez	10524 Human 81601 Mouse
Uniprot	AAH00166 Human NM_006388 Human NM_182709 Human NM_182710 Human NP_006379 Human NP_006379.2 Human NP_874369 Human Q92993 Human
Product By Gene ID	10524
Alternate Names	cPLA2 ESA1EC 2.3.1.48 Histone acetyltransferase HTATIP histone acetyltransferase KAT5 HIV-1 Tat interactive protein HIV-1 Tat interactive protein, 60kDa HTATIP1 HTATIPcPLA2 interacting protein K(lysine) acetyltransferase 5,60 kDa Tat-interactive protein K-acetyltransferase 5 Lysine acetyltransferase 5 PLIPTIP Tat interacting protein, 60kDa Tip60 TIP60cPLA(2)-interacting protein

Research Areas for TIP60

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
DNA Repair