Tau Products

Description

Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Tau's association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Ser 396 (4).

Bioinformatics

Entrez	17762 Mouse 29477 Rat 4137 Human
Uniprot	EAW93573.1 Human NM_005910 Human NM_016834 Human NP_001116539 Human NP_005901 Human NP_058518 Human NP_058519 Human NP_058525 Human P10636 Human P10636-6 Human P10636-8 Human P19332 Rat
Product By Gene ID	4137
Alternate Names	DDPAC FLJ31424 FTDP-17 G protein beta1/gamma2 subunit-interacting factor 1 MGC138549 microtubule-associated protein tau MSTDMAPTL MTBT1Neurofibrillary tangle protein MTBT2 PHF-tau PPND tau TAUPaired helical filament-tau

Research Areas for Tau

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Apoptosis
Cytokine Research
Cytoskeleton Markers
MAP Kinase Signaling
Neurodegeneration
Neuroscience
Phospho-Specific
Stem Cell Markers

Related Tau Blog Posts

Check out the latest blog posts on Tau.

The C99 fragment of amyloid precursor protein (APP) Alzheimer’s Disease (AD) is a neurodegenerative disorder that is characterized by an abundance of the beta-amyloid peptide in the brain.  When AD was first discovered, it was determined that beta-amyloid was produced as a result of the prote...    Read more.

New Study Links Tau Mutations to Microglial Immune Response Tau proteins are abundant in the axons of neurons in the central nervous system (CNS), and play a key role in microtubule formation and stabilization. Antibody studies have identified six tau isoforms, all produced by alternative mRNA splicing of the ...    Read more.

PINK1: All work and no fun The protein PINK1 is a mitochondrial-located serine/threonine kinase (PTK) that maintains organelle function and integrity. It not only protects organelles from cellular stress, but it also uses the selective auto-phagocytosis process for cleaning and...    Read more.

Using Amyloid beta peptides in Alzheimer's Disease Immunization Amyloid beta (AB) peptide has a central role in the neurodegeneration of Alzheimer's disease (AD). Immunization of AD transgenic mice with AB-42 peptide reduces both the spatial memory impairments and AD-like neuropathologic changes.Therapeutic im...    Read more.

HIV-associated neurocognitive disorders involve extracellular Nef-induced modification of lipid rafts and redistribution of Alzheimer’s disease-related proteins Jamshed Arslan, Pharm D, PhD Cholesterol is an essential part of animal cell membranes. Cholesterol-rich lipid rafts maintain the fluidity and protein trafficking of plasma membranes. Cellular ABCA1 protein moves cho...    Read more.

Tau - A microtubule associated protein as a biomarker for Alzheimer's disease The tau protein is a microtubule associated protein found mostly in neuronal cells where it regulates the stability of axonal microtubules as well as kinesin-dependent transport. Tau is relevant in the study of various neurological disorders as ab...    Read more.

Read more Tau related blogs.