SRC1 Products

Description

Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcriptional activity of the nuclear receptor with which they associate. One such coactivator is Steroid Receptor Coactivator-1 (SRC 1).SRC 1 has been shown to interact with and stimulate the transcriptional activity of estrogen, progesterone, retinoic acid, thyroid and glucocorticoid receptors, as well as retinoic X receptor (RXR) in a ligand dependent manner. The amino terminal region of SRC 1 contains a PAS-A-basic helix-loop-helix homology domain which has previously been shown to be dimerization domains in other nuclear transcription factors including the aryl hydrocarbon (Ah) receptor and its heterodimerization partner, ARNT. The carboxy-terminal region of SRC 1 has been shown to possess histone acetyltransferase activity specific primarily for histones H3 & H4.

Bioinformatics

Entrez	17977 Mouse 20779 Mouse 313929 Rat 83805 Rat 8648 Human
Uniprot	NM_003743 Human NP_003734 Human NP_671756 Human NP_671766 Human Q15596 Human Q15788 Human
Product By Gene ID	8648
Alternate Names	bHLHe42 BHLHE74 Class E basic helix-loop-helix protein 74 EC 2.3.1.48 Hin-2 protein KAT13A MGC129719 NCoA-1 nuclear receptor coactivator 1 PAX3/NCOA1 fusion protein Protein Hin-2 Renal carcinoma antigen NY-REN-52 RIP160bHLHe74F-SRC-1 SRC-1 SRC1MGC129720 Steroid receptor coactivator 1 steroid receptor coactivator-1

Research Areas for SRC1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Chromatin Research
Transcription Factors and Regulators