SPANXB1 Products

Description

Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-tail orientation with SPANX family member B2, which appears to be a duplication of the B1 locus. The SPANXB genes are unique members of this gene family, since they contain an additional 18 nt in their coding region compared to the majority of family members. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis. [provided by RefSeq]

Bioinformatics

Entrez	728695 Human
Uniprot	AAH34472 Human NM_032461 Human NP_115850.1 Human
Product By Gene ID	728695
Alternate Names	B1 C Cancer/testis antigen 11.2 cancer/testis antigen family 11, member 2 CT11.1 CT11.2 CT11.2B1 CT11.3 CT11.4 CTp11 dJ171K16.1 NAP-X Nuclear-associated protein SPAN-Xb Nuclear-associated protein SPAN-Xf SPANX family member B/F SPANX family, member B1 SPANX SPANXA SPAN-Xa SPANX-A SPANXB SPAN-Xb SPANX-B SPANXB2 SPANX-C SPANX-D SPANXE SPANX family, member E SPAN-Xf SPANX-F SPANXF1 sperm protein associated with the nucleus on the X chromosome B/F sperm protein associated with the nucleus, X chromosome, family member B1