SorLA Products

Description

SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.

Bioinformatics

Entrez	20660 Mouse 6653 Human
Uniprot	NP_003096 Human NP_003096.1 Human O88307 Mouse Q92673 Human
Product By Gene ID	6653
Alternate Names	C11orf32 chromosome 11 open reading frame 32 FLJ21930 FLJ39258 gp250 Low-density lipoprotein receptor relative with 11 ligand-binding repeats LR11LDLR relative with 11 ligand-binding repeats LRP9 mosaic protein LR11 SorLA SorLA-1SORLA sortilin-related receptor sortilin-related receptor, L(DLR class) A repeats containing sortilin-related receptor, L(DLR class) A repeats-containing Sorting protein-related receptor containing LDLR class A repeats