SMN Products

Description

SMN (Gemin 1) is the central component of a large oligomeric complex (SMN complex), including Gemins 2-7, that is necessary and sufficient for the in vivo assembly of Sm proteins onto the small nuclear (sn)RNAs that mediate pre-mRNA splicing. The SMN complex is found in the cytoplasm and nucleus. Within the nucleus, this protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). Spinal muscular atrophy, a motor neuron disorder, results from reduced levels or a mutation in the Gemin 1 protein.

Bioinformatics

Entrez	20595 Mouse 64301 Rat 6606 Human
Uniprot	AAH00908 Human NM_000344 Human NP_000335.1 Human NP_000335.1 Human NP_059107.1 Human NP_075012 Human NP_075012.1 Human NP_075013.1 Human NP_075014.1 Human NP_075015.1 Human O35876 Rat P97801 Mouse Q16637 Human
Product By Gene ID	6606
Alternate Names	Gemin-1 Kugelberg-Welander disease) SMNC survival motor neuron protein survival of motor neuron 1, telomeric

Research Areas for SMN

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Neurodegeneration
Neuroscience
Transcription Factors and Regulators