Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IP
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ELISA, Func, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE
Species: Hu
Applications: AC
Description
Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc andisoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of theGRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoformp52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shcdoes not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular responseto oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and isindispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome crelease and apoptosis. The expression of isoform p66Shc has been correlated with life span
Bioinformatics
| Entrez |
Mouse
Human
Rat
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
6464 |
| Alternate Names |
- FLJ26504
- p66
- p66SHC
- SH2 domain protein C1
- SHC (Src homology 2 domain containing) transforming protein 1
- SHC (Src homology 2 domain-containing) transforming protein 1
- SHC
- SHCA
- SHC-transforming protein 1
- SHC-transforming protein 3
- SHC-transforming protein A
- Src homology 2 domain-containing-transforming protein C1
|
