Species: Hu
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Monoclonal
Species: Hu
Applications: WB, IP, ICC/IF
Host: Sheep Polyclonal
Species: Hu
Applications: AC
Description
Toll-like receptors (TLRs) play an essential role in the detection and elimination of invading microbes. They are type-1 transmembrane receptors, containing extracellular leucine rich repeats and an intracellular Toll/interleukin-1 receptor (TIR) domain. Upon stimulation, these receptors interact with specific TIR domain-containing adaptor proteins. Five such adaptors have been discovered to date, MyD88, Mal (MyD88 adaptor-like)/TIRAP (TIR domain-containing adaptor protein), Trif (TIR-domain-containing adaptor inducing interferon-beta), TRAM (Trif-related adaptor molecule) and SARM (SAM and ARM-containing protein). Different TLRs use different combinations of these adaptors, leading to the activation of common and unique pathways involved in the elimination of the invading microbe.
Bioinformatics
| Entrez |
Human
Mouse
Mouse
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
23098 |
| Alternate Names |
- KIAA0524SAM domain-containing protein 2
- SAMD2sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila
- SARMFLJ36296
- Sterile alpha and Armadillo repeat protein
- sterile alpha and TIR motif containing 1
- sterile alpha and TIR motif-containing protein 1
- Sterile alpha motif domain-containing protein 2
- Tir-1 homolog
|
