RPSA Products

Description

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. (provided by RefSeq)

Bioinformatics

Entrez	16785 Mouse 29236 Rat 3921 Human
Uniprot	AAH13827 Human NM_001012321 Human NM_002295 Human NM_002295.4 Human NP_002286 Human NP_002286.2 Human P08865 Human
Product By Gene ID	3921
Alternate Names	37 kDa laminin receptor precursor 37/67 kDa laminin receptor 37LRPNEM/1CHD4 67 kDa laminin receptor 67kD, ribosomal protein SA 67LR Colon carcinoma laminin-binding protein LAMBR37 kDa laminin receptor laminin binding protein laminin receptor 1 (67kD, ribosomal protein SA) Laminin receptor 1 Laminin-binding protein precursor p40 LAMR 1 LamR lamR LAMR140S ribosomal protein SA LBP LBP/p40 LRP LRP/LR Multidrug resistance-associated protein MGr1-Ag p40 ribosomal protein SA

Research Areas for RPSA

Find related products by research area and learn more about each of the different research areas below.

Core ESC-Like Genes
Cytoskeleton Markers
Extracellular Matrix
Neuroscience
Stem Cell Markers