RIPK1/RIP1 Products

Description

RIP (Receptor Interacting Protein) is a 74 kD Ser/Thr kinase which interacts with CD95 (Fas/APO1) receptor and the tumor necrosis factor receptor (TNFR1). It is a cell death domain adapter protein which can bind to the adapter proteins TRADD, RAID (CRADD) and TRAF2. RIP contains an N terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C terminal region containing an intracellular death domain motif. RIP activates both p38 MAP Kinase and SAPK families. In vitro, RIP induces apoptosis, as well as SAPK/JNK and NF-kB activation. NF-kB activation through TRADD, TRAF2 and RIP can be triggered also by DR3/APO3 upon activation with APO3/Tweak ligand. DR4 and DR5 also use FADD, TRADD, and RIP in their signal transduction pathways. RIP deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age. RIP possesses kinase activity as it autophosphorylates itself on serine and threonine residues.

Bioinformatics

Entrez	8737 Human
Uniprot	NP_003795 Human Q13546 Human RIK1_HUMAN Human
Product By Gene ID	8737
Alternate Names	Cell death protein RIP EC 2.7.11.1 receptor (TNFRSF)-interacting serine-threonine kinase 1 receptor interacting protein Receptor-interacting protein 1 receptor-interacting serine/threonine-protein kinase 1 Rip1 kinase RIP1 RIP-1 RIPFLJ39204 Serine/threonine-protein kinase RIP

Research Areas for RIPK1/RIP1

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Apoptosis