RGS19 Products

Description

G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.; FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein. SUBCELLULAR LOCATION: Membrane; Lipid-anchor. TISSUE SPECIFICITY: Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.

Bioinformatics

Entrez	10287 Human 56470 Mouse 59293 Rat
Uniprot	AAH01318 Human NM_001039467 Human NM_005873 Human NP_001034556 Human NP_005864 Human P49795 Human
Product By Gene ID	10287
Alternate Names	G alpha interacting protein GAIPG protein signalling regulator 19 G-alpha-interacting protein GNAI3IP guanine nucleotide binding protein alpha inhibiting activity polypeptide 3interacting protein regulator of G-protein signaling 19 regulator of G-protein signalling 19 RGSGAIP

Research Areas for RGS19

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Phospho-Specific
Signal Transduction