RAPGEF5 Products

Description

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM]

Bioinformatics

Entrez	217944 Mouse 362799 Rat 9771 Human
Uniprot	AAH39203 Human NP_036426 Human Q92565 Human
Product By Gene ID	9771
Alternate Names	GFRREPAC Guanine nucleotide exchange factor for Rap1 KIAA0277M-Ras-regulated GEF M-Ras-regulated Rap GEF MRGEF MR-GEFrap guanine nucleotide exchange factor 5 Rap guanine nucleotide exchange factor (GEF) 5 Related to Epac Repac

Research Areas for RAPGEF5

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Neuroscience