PSMD12 Products

Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. [provided by RefSeq]

Bioinformatics

Entrez	5718 Human
Uniprot	NM_002816 Human NP_002807 Human NP_002807.1 Human O00232 Human
Product By Gene ID	5718
Alternate Names	26S proteasome non-ATPase regulatory subunit 12 26S proteasome regulatory subunit p55 26S proteasome regulatory subunit RPN5 MGC75406 p55 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 Rpn5