PSMC6 Products

Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.

Bioinformatics

Entrez	5706 Human
Uniprot	AAH05390 Human NM_002806 Human P62333 Human
Product By Gene ID	5706
Alternate Names	26S protease regulatory subunit 10B 26S protease regulatory subunit S10B 26S proteasome AAA-ATPase subunit RPT4 CADP44 conserved ATPase domain protein 44 MGC12520 p42 P44 proteasome (prosome, macropain) 26S subunit, ATPase, 6 Proteasome 26S subunit ATPase 6 Proteasome subunit p42 SUG2