PSMB10/MECL1 Products

Description

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome.

Bioinformatics

Entrez	19171 Mouse 291983 Rat 5699 Human
Uniprot	AAH17198 Human NP_002792 Human NP_002792.1 Human P40306 Human
Product By Gene ID	5699
Alternate Names	beta2i FLJ00366 LMP10Proteasome subunit beta-2i Low molecular mass protein 10 Macropain subunit MECl-1 MECL1EC 3.4.25.1 MGC1665 Multicatalytic endopeptidase complex subunit MECl-1 proteasome (prosome, macropain) subunit, beta type, 10 proteasome catalytic subunit 2i Proteasome MECl-1 proteasome subunit beta 7i proteasome subunit beta type-10 proteasome subunit MECL1