PRC1 Products

Description

Novel human protein Protein regulator of cytokinesis 1 (PRC1) is involved in cytokinesis. PRC1 is a good substrate for several CDKs in vitro and is phosphorylated in vivo at sites that are phosphorylated by CDK in vitro, strongly suggesting that PRC1 is an in vivo CDK substrate. PRC1 protein levels are high during S and G2/M and drop dramatically after cells exit mitosis and enter G1. PRC1 is a nuclear protein in interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis (1). PRC1, a mitotic spindle-associated Cdk substrate that is essential to cell cleavage, is a microtubule binding and bundling protein both in vivo and in vitro. Over expression of PRC1 extensively bundles interphase microtubules, but does not affect early mitotic spindle organization (2). PRC1 has been shown to down-regulate the GAP activity of MgcRac-GAP during the metaphase and thereby contributes to the correct formation of the spindle (3).

Bioinformatics

Entrez	233406 Mouse 308761 Rat 9055 Human
Uniprot	AAH03138 Human AAH03138.1 Human NM_003981 Human O43663 Human Q9BSB6 Human
Product By Gene ID	9055
Alternate Names	anaphase spindle elongation 1 homolog ASE1 MGC1671 MGC3669 protein regulating cytokinesis 1 protein regulator of cytokinesis 1

Research Areas for PRC1

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Mitotic Regulators
Phospho-Specific