PPM1D Products

Description

PPM1D is encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.

Bioinformatics

Entrez	8493 Human
Uniprot	NP_003611 Human O15297 Human
Product By Gene ID	8493
Alternate Names	EC 3.1.3.16 p53-induced protein phosphatase 1 PP2C-delta PP2C-DELTA protein phosphatase 1D magnesium-dependent, delta isoform protein phosphatase 1D protein phosphatase 2C delta isoform Protein phosphatase 2C isoform delta Protein phosphatase magnesium-dependent 1 delta protein phosphatase, Mg2+/Mn2+ dependent, 1D wild-type p53-induced phosphatase 1 Wip1 WIP1protein phosphatase Wip1

Research Areas for PPM1D

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Cell Cycle and Replication