PKD2L1 Products

Description

PKD2L1 encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Alternative splice variants have been described but their full length sequences have not been determined; FUNCTION: May function as a subunit of an ion channel and act as a transducer of calcium-mediated signaling. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in adult heart, skeletal muscle, brain, spleen, testis, retina and liver. According to Ref.1 expressed at high levels in fetal tissues, including kidney and liver, and down-regulated in adult tissues. It has been found to be expressed in fetal brain, but not expressed in fetal lung, liver or kidney. Isoform 4 appears to be expressed only in transformed lymphoblasts.

Bioinformatics

Entrez	9033 Human
Uniprot	AAH25665 Human NP_057196 Human NP_057196.2 Human Q9P0L9 Human
Product By Gene ID	9033
Alternate Names	PCL PKD2Lpolycystin-L PKDLpolycystin-L1 polycystic kidney disease 2-like 1 protein polycystic kidney disease 2-like 1 Polycystin-2 homolog Polycystin-2L1 polycystin-2L1 Polycystin-L Polycystin-L1 transient receptor potential cation channel, subfamily P, member 3 TRPP3