PKC mu Products

Description

PKC mu is a novel member of the subgroup of atypical protein kinase Cs (PKC). Deduced protein sequence shows strong homology to conserved domains of members of the PKC subfamily. In vitro phorbol ester binding studies and kinase assays with lysates of cells overexpressing PKC mu showed phorbol ester-independent kinase activity, autophosphorylation, and, in normal rat kidney (NRK) cells, predominant phosphorylation of a 30-kDa protein at serine residues. Data suggest a role of PKC mu in signal transduction pathways related to growth control (1). PKC mu is a cytosolic protein, which upon binding to the trans-Golgi network (TGN) regulates the fission of transport carriers specifically destined to the cell surface. (2). Results demonstrate that betagamma subunits of the heterotrimeric G proteins directly activates PKD by interacting with its pleckstrin homology domain (3).

Bioinformatics

Entrez	18760 Mouse 5587 Human 85421 Rat
Uniprot	AAI60015.1 Human NM_002742 Human NP_002733 Human Q15139 Human
Product By Gene ID	5587
Alternate Names	EC 2.7.11 nPKC-D1 nPKC-mu PKCM PKC-MU PKD1 PKDEC 2.7.11.13 PRKCMPKC-mu Protein kinase C mu type protein kinase C, mu Protein kinase D protein kinase D1 serine/threonine-protein kinase D1

Research Areas for PKC mu

Find related products by research area and learn more about each of the different research areas below.

Golgi Apparatus Markers
Phospho-Specific
Signal Transduction