PKC delta Products

Description

PKC-delta has a biological activity which is closely related to Pkc1, and PKC-delta activates the Pkc1-mediated pathway through an activation of the Bck1 kinase. PKC-delta appears to play a critical role in growth control of yeast and mammalian cells. Suppression experiments suggest that PKC-delta desensitizes the pathway by regulating an aspect of G protein function (1). PKC-delta phosphorylates hRad9 in vitro and in cells exposed to genotoxic agents. It has been shown that PKC-delta is required for binding of hRad9 to Bcl-2. In concert with these results, inhibition of PKC-delta attenuates Rad9-mediated apoptosis. These findings demonstrate that PKC-delta is responsible for the regulation of Rad9 in the Hus1-Rad1 complex and in the apoptotic response to DNA damage (2). It has been reported a mechanism for the regulation of peripheral B-cell survival by serine/threonine protein kinase Cdelta (PKC-delta): spontaneous death of resting B cells is regulated by nuclear localization of PKC-delta that contributes to phosphorylation of histone H2B at serine 14 (S14-H2B) (3).

Bioinformatics

Entrez	170538 Rat 18753 Mouse 5580 Human
Uniprot	NM_006254 Human NM_006254. Human NM_006254.3 Human NM_212539 Human NP_006245 Human NP_006245.2 Human P09215 Rat P28867 Mouse Q05655 Human
Product By Gene ID	5580
Alternate Names	EC 2.7.11 EC 2.7.11.13 MAY1 MGC49908 nPKC-delta PKCD PKCy protein kinase C delta type protein kinase C delta VIII protein kinase C, delta

Research Areas for PKC delta

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase
Signal Transduction