PIN/DLC8 Products

Description

DLC8 protein bound efficiently to gephyrin in in vitro binding assays and colocalized with gephyrin during coexpression in HEK293 cells. The binding site for DLC8 was mapped to a fragment of 63 amino acids within the central linker domain of gephyrin. In hippocampal neurons, endogenous DLC8 protein was enriched at synaptic sites identified by synaptophysin and gephyrin immunostaining. Because DLC8 has been described as stoichiometric components of cytoplasmic dynein and myosin-Va complexes, results suggest that motor proteins are involved in the subcellular localization of gephyrin. DLC8 was identified as a transport molecule in the cytoplasm. DLC8 co-localizes with TRPS1 in dot-like structures in the cell nucleus. In an electrophoretic mobility shift assay it was shown that the interaction of DLC8 and TRPS1 lowers the binding of TRPS1 to the GATA consensus sequence. In addition DLC8 is able to suppress the transcriptional repression activity of TRPS1.

Bioinformatics

Entrez	56455 Mouse 58945 Rat 8655 Human
Uniprot	NP_001032583 Human NP_001032584 Human NP_003737 Human NP_003737.1 Human P63167 Human
Product By Gene ID	8655
Alternate Names	cytoplasmic dynein light polypeptide DLC1DNCLC1 DLC8MGC126137 DNCL1MGC126138 dynein light chain 1, cytoplasmic Dynein light chain LC8-type 1 dynein, cytoplasmic, light polypeptide 1 dynein, light chain, LC8-type 1,8 kDa dynein light chain HDLC1 hdlc1 LC8 PINLC8a Protein inhibitor of neuronal nitric oxide synthase

Research Areas for PIN/DLC8

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