PIMT Products

Description

Nuclear receptor coactivators participate in the transcriptional activation of specific genes by nuclear receptors. A new nuclear receptor coactivator-interacting protein, designated PIMT, was identified from a human liver cDNA library by using the coactivator peroxisome proliferator-activated receptor-interacting protein (PRIP) as bait in a yeast 2-hybrid screen. The PIMT cDNA encodes an 852-amino acid protein containing a 9-amino acid methyltransferase motif I (VVDAFCGVG) and an invariant segment (GXXGXXI) found in K-homology motifs of many RNA-binding proteins. Northern blot analysis demonstrated ubiquitous expression of a 3.2-kb PIMT transcript, with highest expression in heart, skeletal muscle, kidney, liver, and placenta. Immunofluorescence studies showed that the PIMT and PRIP proteins are colocalized in the nucleus. PIMT binds 5-adenosyl-L-methionine, the methyl donor for the methyltransfer reaction, and it also binds RNA, suggesting that it is an RNA methyltransferase.

Bioinformatics

Entrez	96764 Human
Uniprot	AAH11999 Human NP_079107 Human Q96RS0 Human
Product By Gene ID	96764
Alternate Names	Cap-specific guanine-N2 methyltransferase CLL-associated antigen KW-2 DKFZp762A163 EC 2.1.1 EC 2.1.1.- HCA137 Hepatocellular carcinoma-associated antigen 137 NCOA6IPSEREX-defined nuclear receptor coactivator 6 interacting protein Nuclear receptor coactivator 6-interacting protein PIMTFLJ22995 PIPMT PRIP-interacting protein PIPMT PRIP-interacting protein with methyltransferase domain PRIP-interacting protein with methyltransferase motif trimethylguanosine synthase 1 trimethylguanosine synthase homolog (S. cerevisiae) trimethylguanosine synthase homolog trimethylguanosine synthase

Research Areas for PIMT

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Transcription Factors and Regulators