Pentraxin 2/SAP Products

Description

Serum Amyloid P (SAP) is a non-fibrillar plasma glycoprotein that belongs to the pentraxin family. It is universally found in amyloid deposits and this is probably due to its specific calcium-dependent binding to motifs present on all types of amyloid fibrils. SAP is also found to prevent fibrillar breakdown by enzymes and it is believed that it helps maintains stability of the amyloid deposits (1,2). It has been shown that SAP binds monocytes with high avidity, but does not bind to erythrocytes, NK cells, T lymphocytes or B lymphocytes (3). SAP production can be induced by exposure to IL-1, IL-6 and IFN-beta. The SAP-inducing activity was neutralized by antibodies to each of the recombinant cytokines (4).

Bioinformatics

Entrez	20219 Mouse 29339 Rat 325 Human
Uniprot	AAH07058 Human AAH07058.1 Human NM_001639 Human NP_001630 Human P02743 Human
Product By Gene ID	325
Alternate Names	9.5S alpha-1-glycoprotein amyloid P component, serum MGC88159 PTX2serum amyloid P-component SAPpentaxin-related Serum Amyloid P component