PATZ Products

Description

PATZ is encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq]

Bioinformatics

Uniprot	NM_032051 Human NP_055138 Human NP_114440 Human NP_114440.1 Human Q9HBE1 Human
Product By Gene ID	23598
Alternate Names	dJ400N23 MAZRPOZ-, AT hook-, and zinc finger-containing protein 1 PATZZinc finger and BTB domain-containing protein 19 POZ (BTB) and AT hook containing zinc finger 1 Protein kinase A RI subunit alpha-associated protein RIAZBTB/POZ domain zinc finger transcription factor ZBTB19BTB-POZ domain zinc finger transcription factor Zinc finger protein 278Zinc finger sarcoma gene protein ZNF278POZ-AT hook-zinc finger protein ZSGMAZ-related factor