PAK3 Products

Description

p21-activated kinase 3 (PAK3) is a member of a family of serine/threonine protein kinase defined by their interaction with the small GTPases, Cdc42 and Rac (1-2). The PAK proteins can be essentially divided into two categories, group I (PAK1, PAK2 and PAK3) and group II (PAK4, PAK5 and PAK6), based on their structures (3). All six PAKs play an important role in diverse cellular processes, including cytoskeletal dynamics, growth/apoptotic signal transduction through MAP kinases, and regulation of transcription factors (4). PAK3 as well as PAK1 are mostly expressed in the nervous system and particularly in the hippocampus, in which they show a diffuse distribution throughout the soma and proximal dendrites (5). Mutations in PAK3 have been linked to nonsyndromic X-linked mental retardation (6).

Bioinformatics

Uniprot	NM_002578 Human NP_002569 Human O75914 Human
Product By Gene ID	5063
Alternate Names	Beta-PAK beta-PAK bPAK CDKN1A EC 2.7.11 EC 2.7.11.1 hPAK3 mental retardation, X-linked 47 MRX30 MRX47 Oligophrenin-3 oligophrenin-3 OPHN3 p21 (CDKN1A)-activated kinase 3 p21 protein (Cdc42/Rac)-activated kinase 3 p21-activated kinase 3 PAK-3 PAK3beta serine/threonine-protein kinase PAK 3

Research Areas for PAK3

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Protein Kinase