PAG3 Products

Description

PAG3 encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Bioinformatics

Uniprot	NP_003878 Human NP_003878.1 Human O43150 Human
Product By Gene ID	8853
Alternate Names	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 centaurin, beta 3 CENTB3 DDEF2FLJ42910 development and differentiation enhancing factor 2 Development and differentiation-enhancing factor 2 KIAA0400AMAP2 Pap-alpha PAPPAG3 Paxillin-associated protein with ARF GAP activity 3 PYK2 C terminus-associated protein Pyk2 C-terminus-associated protein SHAG1

Research Areas for PAG3

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Cellular Markers
Cytoskeleton Markers
Phospho-Specific