p53R2 Products

Description

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. p53R2 is induced by the reagents, ultraviolet and g-irradiation that cause DNA damages. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression. p53R2 is an important target of p53 for tumour suppression.

Bioinformatics

Uniprot	BAA92434 Human NP_001165948 Human NP_056528 Human Q7LG56 Human
Product By Gene ID	50484
Alternate Names	EC 1.17.4.1 MGC102856 MGC42116 MTDPS8A MTDPS8B p53-inducible ribonucleotide reductase small subunit 2 homolog p53-inducible ribonucleotide reductase small subunit 2-like protein p53R2 P53R2DKFZp686M05248 PEOA5 ribonucleoside-diphosphate reductase subunit M2 B ribonucleotide reductase M2 B (TP53 inducible) TP53-inducible ribonucleotide reductase M2 B

Research Areas for p53R2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Checkpoint signaling
DNA Double Strand Break Repair
DNA Repair
Hypoxia
Modulation of DNA Pools
Phospho-Specific