P11 Products

Description

p11 increases localization of 5-HT1B receptors at the cell surface. It is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant.

Bioinformatics

Uniprot	NP_001165910 Human NP_006016.1 Human P21128 Human
Product By Gene ID	8909
Alternate Names	EC 3.1 endonuclease, polyU-specific MGC133268 P11,26 serine protease Placental protein 11 poly(U)-specific endoribonuclease PP1122 serine protease Protein endoU PRSS26 Uridylate-specific endoribonuclease