Species: All-NA
Applications: ELISA, ICC/IF, IHC
Host: Rabbit Polyclonal
Description
The nonapeptide hormones Arginine Vasopressin (ARG-Vasopressin or AVP) and Oxytocin are synthesized in the supraoptic and paraventricular nuclei of the hypothalamus together with their respective "carrier" proteins, the neurophysins. Vasopressin and Oxytocin are produced by separate populations of magnocellular neurons in both nuclei. Neurophysin I (NPI) and Neurophysin II (NPII) function as carrier proteins for Oxytocin and Vasopressin, respectively. Oxytocin is a pituitary hormone which induces uterine contractions during childbirth and the ejection of milk from the mammary glands during nursing. Vasopressin is involved in the metabolism of water and electrolytes and has been identified as a vasoconstrictor. Both Neurophysin genes exist as three exons, with each exon encoding a functional protein domain. Studies show that the identically conserved middle region (exon B) is involved in NP-NP homodimer formation as well as being the site for the Glycine 17 to Valine point mutation responsible for familial diabetes insipidus. The genes encoding Neurophysin I and II map to human chromosome 20p13.
Bioinformatics
| Uniprot |
Human
Rat
|
| Product By Gene ID |
5020 |
| Alternate Names |
- MGC126890
- MGC126892
- neurophysin I
- OT
- OT-NPI
- oxytocin, prepro- (neurophysin I)
- oxytocin, prepropeptide
- oxytocin-neurophysin 1
- oxytocin-neurophysin I, preproprotein
|
