Orai2 Products

Description

STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry(SOCE). SOCE allows rapid Ca2+ efflux from the endoplasmic reticulum (ER), following the emptying of intracellularCa2+ stores. STIM (sensors stromal interaction molecule) proteins, STIM1 and STIM2, serve as ER Ca2+ sensors. Theycontain N'-terminal Ca2+-sensing EF-hand domains and are localized to the tubular ER. Following Ca2+ store depletion,STIMs rapidly cluster and relocalize to the plasma membrane-adjacent ER regions, where they oligomerize and form'puncta'. Orai proteins, Orai1, Orai2 and Orai3, are STIM binding partners that form the pore of the channel. Oraiproteins are uniformly distributed in the plasma membrane and exist as dimers in the resting state. STIM activationinduces tetramerization of Orai proteins and subsequent STIM-Orai colocalization, which forms the activestore-operated calcium channel

Bioinformatics

Uniprot	NP_001119812 Human NP_116220 Human NP_116220.1 Human Q96SN7 Human
Product By Gene ID	80228
Alternate Names	CAP-binding protein complex interacting protein 2 CAP-binding protein complex-interacting protein 2 CBCIP2C7orf19FLJ12474 chromosome 7 open reading frame 19 FLJ14733 H_NH0514P08.8 MEM142B ORAI calcium release-activated calcium modulator 2 protein orai-2 putative protein ORAI2-2 TMEM142B Transmembrane protein 142BFLJ44818