NALP4 Products

Description

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).

Bioinformatics

Uniprot	AAL35293 Human NP_604393 Human
Product By Gene ID	147945
Alternate Names	Cancer/testis antigen 58 CLR19.5 CT58PYRIN and NACHT-containing protein 2 FLJ32126 NACHT, leucine rich repeat and PYD containing 4 NACHT, LRR and PYD domains-containing protein 4 NALP4NACHT, LRR and PYD containing protein 4 NLR family, pyrin domain containing 4 nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 4 PAN2Ribonuclease inhibitor 2 PYPAF4PAAD and NACHT-containing protein 2 RNH2PYRIN-containing APAF1-like protein 4

Related NALP4 Blog Posts

Check out the latest blog posts on NALP4.

NALP4 - Mediator of Programmed Cell Death The NALP family consists of cytoplasmic proteins within the larger CATERPILLER protein family. There exist in short forms (such as NALP4) and long forms (NALP1). NALP proteins include the apoptosis regulator apoptotic protease activating factor 1 (APA...    Read more.

Pyroptosis: Mechanisms mediating cell death and pro-inflammatory cytokine release By Victoria OsinskiPyroptosis is an inflammatory form of programmed cell death characterized by the release of pro-inflammatory cytokines IL-1 beta and IL-18.1,10 It is a process distinct from apoptosis and necrosis (T...    Read more.

Read more NALP4 related blogs.