MMP26 Products

Description

Matrix metalloproteinase 26 (MMP-26) is specifically expressed in cancer cells of epithelial origin, including carcinomas of lung, prostate and breast. Several unique structural and regulatory features, including an unusual 'cysteine-switch' motif, discriminate broad-spectrum MMP-26 from most other MMPs. MMP-26 efficiently cleaves fibrinogen and extracellular matrix proteins, including fibronectin, vitronectin and denatured collagen (1). Expression analysis revealed that matrilysin-2 is detected not only in placenta and uterus but is widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines. These data together with its broad spectrum of proteolytic activity, suggest that MMP-26 may play a role in some of the tissue-remodeling events associated with tumor progression (2). A study of MMP-26 mRNA steady states levels reveals, among the tissue examined, a specific expression in placenta. MMP-26 mRNA could also be detected in several human cell lines such as HEK 293 kidney cells and HFB1 lymphoma cells (3)

Bioinformatics

Entrez	56547 Human
Uniprot	MM26_HUMAN Human NM_021801 Human NP_068573 Human Q9NRE1 Human
Product By Gene ID	56547
Alternate Names	EC 3.4.24.- endometase Endometase matrilysin 2 matrilysin-2 Matrilysin-2 matrix metallopeptidase 26 matrix metalloproteinase 26 matrix metalloproteinase-26 MGC126590 MGC126592 MMP-26