Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, ChIP
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE
Species: Hu
Applications: AC
Description
Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005).[supplied by OMIM]
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
57506 |
| Alternate Names |
- CARD adapter inducing interferon beta
- CARD adapter inducing interferon-beta
- CARD adaptor inducing IFN-beta
- Cardif
- CARDIF
- DKFZp547C224
- DKFZp666M015
- FLJ27482
- IFN-B promoter stimulator 1
- Interferon beta promoter stimulator protein 1
- interferon-beta promoter stimulator protein 1
- IPS-1FLJ41962
- IPS1MGC3260
- KIAA1271FLJ35386
- mitochondrial antiviral signaling protein
- mitochondrial antiviral-signaling protein
- mitochondrial viral signaling protein
- Putative NF-kappa-B-activating protein 031N
- virus-induced signaling adapter variant 1b
- virus-induced signaling adaptor variant 1a
- Virus-induced-signaling adapter
- VISAFLJ38051
|
