LIM kinase 2 Products

Description

LIM-kinase 2 (LIMK2), a 75-kDa member of the LIM kinase family, is responsible for regulating actin polymerization via phosphorylation and inactivation of the actin depolymerizing factors ADF/cofilin (1). LIMK2 protein is found in the cytoplasm during interphase, redistributed to the mitotic spindle and then to the spindle midzone during anaphase to telophase (2). It has been shown that ROCK, a downstream protein kinase of Rho, activates LIMK2 by directly phosphorylates threonine 505 residue. Since activity of LIMK2 is cell cycle dependant, LIMK2 activity is markedly increased when HeLa cells are synchronized at mitosis with nocodazole treatment (3).

Bioinformatics

Entrez	16886 Mouse 29524 Rat 3985 Human
Uniprot	AAH13051 Human AAH13051.1 Human NM_001031801 Human NP_001026971.1 Human NP_005560 Human NP_057952 Human P53667 Human P53671 Human Q99464 Human
Product By Gene ID	3985
Alternate Names	EC 2.7.11.1 LIM domain kinase 2 LIMK-2

Research Areas for LIM kinase 2

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Phospho-Specific
Protein Kinase