Laminin beta 1 Products

Description

Laminins are essential and abundant structural non-collagenous glycoproteins localizing to basement membranes. Basement membranes (cell-associated extracellular matrices (ECMs)) are polymers of Laminins with stabilizing type IV collagen networks, nidogen and several proteoglycans. Basement membranes are found under epithelial layers, around the endothelium of blood vessels and surrounding muscle, peripheral nerve and fat cells. Formation of basement membranes influences cell proliferation, phenotype, migration, gene expression and tissue architecture. Each Laminin is a heterotrimer of alpha, beta and gamma chain subunits that undergoes cell-secretion and incorporation into the ECM. Laminins can self-assemble and bind to other matrix macromolecules, and have unique and shared cell interactions mediated by Integrins, dystroglycan and cognate Laminin receptors. The human Laminin gamma-1 gene maps to chromosome 1q31 and is ubiquitously expressed in tissues that produce basement membranes.

Bioinformatics

Entrez	16777 Mouse 3912 Human
Uniprot	P07942 Human
Product By Gene ID	3912
Alternate Names	CLM cutis laxa with marfanoid phenotype Laminin B1 chain laminin subunit beta-1 laminin, beta 1 Laminin-1 subunit beta Laminin-10 subunit beta Laminin-12 subunit beta Laminin-2 subunit beta Laminin-6 subunit beta Laminin-8 subunit beta MGC142015

Research Areas for Laminin beta 1

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Apoptosis
Cancer
Cellular Markers
Cytoskeleton Markers
Extracellular Matrix
Neuroscience
Signal Transduction
Tumor Suppressors