Kos1/Tnk1 Products

Description

Kinase of embryonic stem cells (Kos1) is a nonreceptor protein tyrosine kinase (NRPTK) and a new member of the Ack family of NRPTKs. Kos1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Kos1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Kos1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.

Bioinformatics

Entrez	83813 Mouse
Uniprot	Q99ML2 Mouse
Alternate Names	CD38 negative kinase 1;Kinase of embryonic stem cells;MGC46193;non-receptor tyrosine kinase;Non-receptor tyrosine-protein kinase TNK1;TNK1;tyrosine kinase, non-receptor 1;tyrosine kinase, non-receptor, 1