KLC1 Products

Description

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq]

Bioinformatics

Entrez	3831 Human
Uniprot	NM_005552 Human NP_005543.2 Human
Product By Gene ID	3831
Alternate Names	hKLC1B hKLC1G hKLC1J hKLC1S kinesin 2 60/70kDa kinesin 2 kinesin light chain 1 KLC 1 KLChKLC1N KNS2AhKLC1P KNS2hKLC1R medulloblastoma antigen MU-MB-2.50 MGC15245