KDELR2 Products

Description

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.

Bioinformatics

Entrez	11014 Human
Uniprot	NM_006854 Human NP_006845.1 Human P33947 Human
Product By Gene ID	11014
Alternate Names	ELP-1(Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 ER lumen protein retaining receptor 2 ERD2.2FLJ45532 ERD2-like protein 1 ERD-2-like protein KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 KDEL endoplasmic reticulum protein retention receptor 2 KDEL receptor 2