KCNN2 Products

Description

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq)

Bioinformatics

Entrez	140492 Mouse 3781 Human 54262 Rat
Uniprot	NP_067627 Human NP_067627.2 Human NP_740721 Human Q9H2S1 Human
Product By Gene ID	3781
Alternate Names	hSK2 KCa2.2SKCA2 potassium intermediate/small conductance calcium-activated channel, subfamilyN, member 2 SK2apamin-sensitive small-conductance Ca2+-activated potassium channel SKCa 2 SKCa2 small conductance calcium-activated potassium channel protein 2